1

Pharmacologic modulation of systemic inorganic phosphate levels restores the impaired phagocytosis of Kupffer cells and improves liver function in murine models of chronic liver failure

International Immunopharmacology

4.7

唐群

2025.9.23

2

Secondary structure transitions and dual PIP2 binding define
cardiac KCNQ1-KCNE1 channel gating

Cell Research

28.2

张进

2025.8.29

3

Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth

Nature cancer

28.5

李建明

2025.8.21

4

NSUN5 Mediates Resistance to Doxorubicin via Up-regulation of DNA Damage Repair Proteins BRCA2 and BRIP1 in Colorectal Cancer

american journal of pathology

3.9

李建明

2025.7.24

5

Pharmacologic modulation of systemic inorganic phosphate levels restores the impaired phagocytosis of Kupffer cells and improves liver function in murine models of chronic liver failure

International Immunopharmacology

4.8

唐群

2025.7.24

6

Identification of a 10-species microbial signature of inflammatory bowel disease by machine learning and external validation

cell regeneration

4.7

陈晔光

2025.7.14

7

PDGFR-β/Cav1-induced autophagy via mTOR/FIP200/ATG13 activation in cancer-associated fibroblasts promotes the malignant progression of breast cancer

J TRANSL MED

7.5

熊丽霞

2025.7.11

8

Bioadhesive drug-loaded microparticles prolong drug retention in the middle ear and ameliorate cisplatin-induced hearing loss

Journal of Controlled Release

11.5

陈红平

2025.7.10

9

Positional BMP signaling orchestrates villus length in the small intestine

nature communications

15.7

陈晔光

2025.7.1

10

Transformer optimization with meta learning on pathology images for breast cancer lymph node micrometastasis

npj digital medicine

15.1

李建明

2025.7.09

11

eIF5A maintains intestinal epithelial homeostasis by sustaining intestinal stem cells

cell regeneration

4.7

陈晔光

2025.6.9

12

ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis
to sustain glioblastoma survival under glucose deprivation

Cell Death Discovery

7

边学利

2025.6.4

13

Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment

Gut Microbes

12.2

李建明

2025.6.28

14

YTHDF2-KIF26B-Wnt signaling forms a positive-feedback regulatory loop to maintain intestinal stem cell stemness

cell regeneration

4.7

陈晔光

2025.6.20

15

Resveratrol inhibits autophagy in cardiomyocytes subjected anoxia/reoxygenation injury: involved in VDAC1/PINK1/Parkin pathway

Toxicol Appl Pharmacol

3.4

廖章萍

2025.5.29

16

The critical role of BMP signaling in gastric epithelial cell differentiation revealed by organoids

cell regeneration

4.7

陈晔光

2025.5.16

17

Mechanistic insights into the role of FAT10 in modulating NCOA4-mediated ferroptosis in pancreatic acinar cells during acute pancreatitis

Cell Death & Diease

9.6

邵江华

2025.5.15

18

The role of ferroptosis in breast cancer: Tumor progression, immune microenvironment interactions and therapeutic interventions

European Journal of Pharmacology

4.7

熊丽霞

2025.4.8

19

Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammation

EMBO reports

6.2

陈晔光

2025.4.30

20

Bioactive natural alkaloid
6−Methoxydihydrosanguinarine exerts anti−tumor effects in hepatocellular carcinoma cells via ferroptosis

Frontiers in Pharmacology

4.8

边学利

2025.4.24

21

NUB1 reduction promotes PCNA-mediated tumor growth by disturbing the PCNA polyubiquitination/NEDDylation in hepatocellular carcinoma cells

Cell Death & Diease

9.6

邵江华

2025.3.31

22

Self-synergy-powered Ni/Fe nanocube-based cholesterol detection with
dual modes

Talanta

6.1

严喜鸾

2025.3.1

23

Spermine attenuates TGF-β-induced EMT by downregulating fibronectin

Journal of Biological Chemistry

3.9

陈晔光

2025.2.25

24

Dysbiosis and extraintestinal cancers.

Journal of Experimental & Clinical Cancer Research

12.8

邓欢

2025.2.21

25

E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

MedComm

10.7

黄璇

2025.12.7

26

TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cells

Cell Oncol (Dordr)

4.8

黄璇

2025.12.29

27

Pharmacologic deprivation of serum inorganic phosphate ameliorates renal fibrosis via the modulation of systemic inflammation

European Journal of Pharmacology

4.7

唐群

2025.12.20

28

Caveolin-1 drives vasculogenic mimicry in lung adenocarcinoma through autophagy-mediated glycolytic reprogramming

Cellular Signalling

3.7

熊丽霞

2025.11.18

29

Caveolin-1 Drives Ferroptosis in MDSCs via PKA-DRP1-Mediated ER‒mitochondria Crosstalk to Shape Breast Cancer Immunosuppression

Free Radical Biology and Medicine

8.2

熊丽霞

2025.11.13

30

Inhalation formulations targeting nitric oxide pathways for pulmonary hypertension therapy: current advances and future directions.

International Journal of Pharmaceutics

5.9

刘松杨

2025.11.12

31

Lactylation enhances the activity of lactate dehydrogenase A and promotes the chemoresistance to cisplatin through facilitating DNA non-homologous end junction in lung adenocarcinoma.

Advanced Science

14.1

王建斌

2025.10.11

32

Design and synthesis of piperine-based photoaffinity probes for revealing potential targets of piperine in neurological disease

Chemical Communications（Chem Commun (Camb) ）

4.2

张春波

2025.1.7

33

Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017-2020 National Health and Nutrition Examination Survey

Frontiers in Nutrition

5.1

王恺

2025.1.29

34

Standard: Human gastric organoids

cell regeneration

4.7

陈晔光

2025.1.14

35

AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases

Nature

48.5

张龙

2025.09.25

36

EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy

Advanced Science

14.1

张龙

2025.09.12

37

Lactylation in Cancer: Advances, Challenges, and Future Perspectives

Cancer Research

16.6

张龙

2025.09.02

38

Tumor-Immune Cell Interactions in Cancer Progression

Cancer Research

16.6

张龙

2025.08.15

39

PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma

AUTOPHAGY

14.6

王建斌

2025.07.23

40

UCHL5 is a putative prognostic marker in renal cell carcinoma: a study of UCHL family

Molecular Biomedicine

10.1

张龙

2025.07.22

41

Targeting Mutant Protein Kinase B with Lysine-Selective Salicylaldehyde Inhibitors and Zn2⁺ Chelation: A Novel Therapeutic Strategy

Molecular Biomedicine

10.1

张龙

2025.07.21

42

Combined inhibition of protein kinase B and enhancer of zeste homolog 2: a novel strategy to induce triple-negative breast cancer cell death

Molecular Biomedicine

10.1

张龙

2025.07.21

43

Protocol for label-free quantitative lysine lactylproteome profiling

STAR Protocols

1.3

张龙

2025.07.20

44

Chronic Stress Synergizes with Listeria monocytogenes to Promote Intestinal Adenomagenesis via Myeloid-Derived Suppressor Cells.

Frontiers in Immunology

5.9

邓欢

2025.07.02

45

Cloche/Npas4l is a pro-regenerative platelet factor during zebrafish heart regeneration

Developmental Cell

10.7

熊敬维

2025.06.24

46

Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing

Nature Cell Biology

19.1

张龙

2025.05.27

47

High-resolution spatiotemporal mapping: a comprehensive view of eukaryotic cell cycle proteome dynamics

Signal Transduction and Targeted Therapy

52.7

张龙

2025.05.22

48

Specific signaling pathways mediated programmed cell death in tumor microenvironment and target therapies

DISCOVER ONCOLOGY

2.9

祝新根

2025.05.16

49

Dual inhibition of PD-1 and LAG-3: uncovering mechanisms to reverse T cell exhaustion and enhance anti-tumor immunity

Science Bulletin

21.1

张龙

2025.04.15

50

Bending and Scission: When the Membraneless Condensates Meet Endosome Membrane

MedComm

10.7

张龙

2025.04.01

51

Identification of TAP2 as a novel immune target in human cancers: insights from integrated bioinformatics and experimental approaches

European journal of medical research

3.4

祝新根

2025.03.13

52

Emerging roles of lysine lactyltransferases
and lactylation

nature cell biology

19.1

张龙，任江

2025.02.13

53

Targeting FOXM1 condensates reduces breast tumour growth and metastasis

Nature

48.5

张龙

2025.01.25

54

Ketogenic diet and cancer: multidimensional exploration and research

Science China Life Sciences

9.5

张龙

2025.01.14

55

Mucosal immune response in biology, disease prevention and treatmen

Signal Transduction and Targeted Therapy

52.7

张龙

2025.01.08

56

ATP6AP1 promotes cell proliferation and tamoxifen resistance in luminal breast cancer by inducing autophagy

Cell death & disease

9.6

罗时文

2025 May 15

57

Emerging roles of lysine lactyltransferases and lactylation

nature cell biology

19.1

任江

2025.04

58

Enantioselective Synthesis of Chiral Sulfinamidines via Asymmetric Amination of Sulfenamides Using a Chiral Phosphoric Acid Catalyst

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

16.9

熊小东

2025

59

Nuclear ubiquitination permits Hippo–YAP signal for liver development and tumorigenesis

Nature Chemical Biology

13.7

赵冰

2025

60

Human meibomian gland organoids to study epithelial homeostasis and dysfunction

Protein & Cell

12.8

赵冰

2025

61

LncRNA HOTTIP modulated by Hedgehog signaling drives colorectal cancer progression

Cell Death & Disease

9.6

赵冰

2025

62

Manipulation of Wnt/β-Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods.

9.1

赵冰

2025

63

Asymmetric chloro- and selenocyclization of 2-alkenyl anilides enabled by tertiary ammonium salt catalysis

Chinese Chemical Letters

8.9

熊小东

2025

64

PharmaFormer predicts clinical drug responses through transfer learning guided by patient derived organoid

NPJ precision oncology

8

赵冰

2025

65

Vascularized organoid-on-a-chip for centimeter-scale organoid cultivation

Bio-Design and Manufacturing

7.6

赵冰

2025

66

Human adrenocortical organoids for tissue regeneration anddisease modeling

Stem Cell Reports

5.1

赵冰

2025

67

Asymmetric Halocyclization of 2‑Anilidostyrenes Using N‑Haloamides Enabled by Chiral Anion Phase-Transfer Catalysis

Organic Letters

5

熊小东

2025

68

Modular Access to Sulfondiimidoyl Fluorides by NaH-Mediated Fluorination of Sulfenamides

Organic Letters

5

熊小东

2025

69

HNRNPC stabilizes m6A-modified AC145207.5 to accelerate tumorigenesis in colorectal cancer by impeding the Nrf2/GPX4 axis-mediated ferroptosis

Non-coding RNA Research

4.7

刘丹

2025

70

Atroposelective synthesis of N–N axially chiral pyrrolylamides by combined-acid catalytic Paal–Knorr reaction

Chemical Communications

4.2

熊小东

2025

71

Design and synthesis of piperine-based photoaffinity probes for revealing potential targets of piperine in neurological. disease

Chemical Communications

4.2

廖璠

2025

72

Mechanisms of corn silk polysaccharide in promoting colorectal Cancer progression: A multi-omics approach to microbiota, metabolomics, and transcriptomics

Journal of Functional Foods

4

刘丹

2025

73

Solvent-Dependent Oxidative Ring Opening of Cyclopropylamides Mediated by Halogen Bonding

Journal of Organic Chemistry

3.6

熊小东

2025