PI课题组

边学利课题组

基础信息

bianxueli@ncu.edu.cn

B

人简介:

南昌大学基础医学院特聘教授教育部实体肿瘤分子靶向医药基础研究创新中心与基础医学院独立PI,博士生导师。

2018年获得厦门大学细胞生物学博士学位2021年聘为南昌大学“学科优秀人才”引进人才;中国细胞生物学会细胞代谢分会委员发表SCI论文10余篇,被引用超过2000

研究方向:

致力于理解细胞代谢在肿瘤发生发展命运调控及免疫调控中的功能及分子机制,通过研究肿瘤代谢重编程的分子机制,揭示新的肿瘤代谢标志物和分子靶点,为肿瘤的精准化治疗提供理论基础和有效方案。主要研究方向:代谢酶的时空调控、蛋白质翻译后修饰、代谢物作为信号分子的功能及代谢酶的非经典功能

代表性论文(不超过10篇):

[1] Bian XL#, Chen HZ#, Yang PB#, Li YP#, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q*. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nature Communications. 2017.8:14420.

[2] Bian XL#, Liu R#, Meng Y#, Xing DM*, Xu DQ*, & Lu ZM*. Lipid metabolism and cancer[J]. Journal of Experimental Medicine, 2021, 218(1).

[3] Xu D#, Shao F#, Bian XL#, Meng Y, Liang TB, Lu ZM*. The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies[J]. Cell Metabolism, 2021, 33(1): 33-50.

[4] Hou PP#, Luo LJ#, Chen HZ#, Chen QT#, Bian XL#, Wu SF, Zhou JZ, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen QH, Zhou DW, Wu Q*. Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment. MOLECULAR CELL. 2020 May 20;S1097-2765(20)30305-1.

[5] Bian, X. #, Jiang, H. #, Meng, Y. #, Li, Y. P. #, Fang, J. *, & Lu, Z. *. Regulation of gene expression by glycolytic and gluconeogenic enzymes[J]. Trends in Cell Biology, 2022.

[6] Shao F#, Bian XL#, Jiang HF, Zhao GX, Zhu L, Xu DQ,Wang S, Guo W, Xing DM, Xue Q, Gao YB*, He J*, Lu ZM*. Association of phosphoenolpyruvate carboxykinase 1 protein kinase activity-dependent sterol regulatory element-binding protein 1 activation with prognosis of oesophageal carcinoma[J]. European Journal of Cancer, 2021, 142: 123-131.

[7] Li Y, Zhang F, Hu F, Tong R, Wen Y, Fu G, Bian X*. ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis to sustain glioblastoma survival under glucose deprivation. Cell Death Discovery. 2025 Jun 4;11(1):266.