个人简介：

张春波，教授，博导，江西省“双千”计划-自然科学领军人才、“青年井冈学者”、省“杰青”获得者。香港中文大学药学博士，美国佐治亚大学药学院博士后。现任南昌大学研究生院副院长，教育部实体肿瘤分子靶向医药基础研究创新中心副主任，新药靶点发现与确证江西省重点实验室主任，江西省细胞生物学学会理事长， Military Medical Research和《肿瘤药学》编委，国际抗癫痫联盟-植物药特别委员会委员，国家重大新药创制、国家重点研发计划、科技部战略专项会评评委。在药物靶点发现和药物筛选方面取得了一系列突出成果，在Adv Drug Deliv Rev、J Adv Res、 eLife、Epilepsia 等著名期刊上发表高水平论文40余篇。主持国家自然科学基金6项(含面上、国际合作等项目)、省自然科学基金重点项目3项。现为 Nature Communications、Molecular Therapy、eLife、Epilepsia、Neuropharmacology、Liver International等高水平SCI杂志审稿人。

研究方向：

致力于耐药性癫痫和基因治疗研究，其目的是开发有效治疗肿瘤、耐药性癫痫等疾病的新手段，并研发相应的核酸与蛋白质大分子药物。

代表性论文（不超过10篇）：

[1] Zhang C, Liu D. Transcription Factor Binding Site in Promoter Determines the Pattern of Plasmid-Based Transgene Expression In Vivo. Pharmaceutics. 2024 Apr 15;16(4):544. doi: 10.3390/pharmaceutics16040544. PMID: 38675205; PMCID: PMC11055139.

[2] Shen L, Yang Y, Lu L, Huang J, He W, Zhao C, Guo F, Zhang C, Zhong H, Liao F. Design and synthesis of piperine-based photoaffinity probes for revealing potential targets of piperine in neurological disease. Chem Commun (Camb). 2025 Jan 7;61(4):669-672. doi: 10.1039/d4cc04330h. PMID: 39628399

[3] Zhao Z, Zhu J, Zhou L, Sun N, Chang K, Hu X, Hu Y, Ren M, Cheng Y, Xu D, Xin H, Zhang C. Establishment of a hydrodynamic delivery system in ducks. Transgenic Res. 2024 Apr;33(1-2):35-46. doi: 10.1007/s11248-024-00377-x. Epub 2024 Mar 9. PMID: 38461212.

[4] Zhu H, Wu Z, Yu Y, Chang K, Zhao C, Huang Z, He W, Luo Z, Huang H, Zhang C. Integrated non-targeted metabolomics and network pharmacology to reveal the mechanisms of berberine in the long-term treatment of PTZ-induced epilepsy. Life Sci. 2024 Jan 1:336:122347. doi: 10.1016/j.lfs.2023.122347.

[5] Zhao C, Rollo B, Shahid Javaid M, Huang Z, He W, Xu H, Kwan P, Zhang C. An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds. J Adv Res. 2024 Oct;64:249-262. doi: 10.1016/j.jare.2023.11.022. Epub 2023 Nov 22. PMID: 37995945; PMCID: PMC11464642.

[6] Zeng Y, Lv Y, Hu M, Guo F, Zhang C. Curcumin-loaded hydroxypropyl-β-cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment. Xenobiotica. 2022 Oct 24:1-11. doi: 10.1080/00498254.2022.2136044. Epub ahead of print. PMID: 36227237.

[8] Liu Z, Wang M, Zhang C, Zhou S, Ji G. Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology. Diabetes Metab Syndr Obes. 2022 Mar 3;15:695-711.

[7] Ren M, Pan J, Yu X, Chang K, Yuan X, Zhang C. CTRP1 prevents high fat diet-induced obesity and improves glucose homeostasis in obese and STZ-induced diabetic mice. J Transl Med. 2022 Oct 4;20(1):449. doi: 10.1186/s12967-022-03672-5. PMID: 36195912; PMCID: PMC9533627.[8]Liu Z, Wang M, Zhang C, Zhou S, Ji G. Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology. Diabetes Metab Syndr Obes. 2022 Mar 3;15:695-711.

[9] Zhang C, Zhong T, et, al. The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. Elife. 2021 Nov 5;10:e70672.

[10] Fei Z, Hu M, Baum L, Kwan P, Hong T, Zhang C. The potential role of human multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 2 (MRP2) in the transport of Huperzine A in vitro. Xenobiotica. 2020 Mar;50(3):354-362.