个人简介：

南昌大学基础医学院教授，博士生导师。南昌大学生物医学研究院院长，肿瘤生物学江西省重点实验室主任，教育部南昌大学实体肿瘤研究创新中心学术方向带头人。

1994年于香港中文大学获得博士学位，后于美国纽约州立大学做博士后，2001年进入美国康奈尔大学做助理研究员。2011年被引进到南昌大学工作，先后任特聘教授和二级教授。入选百千万人才工程国家级人选，江西省赣鄱英才555工程首批人选、获得中国侨界创新人才贡献奖，江西省自然科学技术奖二等奖。在Cancer Cell，Nature Cell Biology，Cell Research, Advanced Science等杂志发表论文60多篇。

研究方向：

利用分子生物学，细胞生物学，生物化学等手段研究肿瘤发生发展过程中的信号转导通路,特别是基于肿瘤细胞中普遍存在着能量和物质代谢异常的生化特征, 系统研究这些特征与肿瘤的生长、侵袭和转移的关系，确定肿瘤细胞赖以生存的关键代谢通路和靶点，并设计相应的干预策略，以期更有效的防治肿瘤。

代表性论文（不超过10篇）：

[1] Jian-Bin Wang, Jon W Erickson, Reina Fuji, Sekar Ramachandran, Ping Gao, Ramani Dinavahi, Kristin F Wilson, Andre L B Ambrosio, Sandra M G Dias, Chi V Dang, Richard A Cerione. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell (2010) 18: 207-219

[2] Tianyu Han, Weihua Zhan, Mingxi Gan, Fanrong Liu, Bentong Yu, Y. Eugene Chin & Jian-Bin Wang*. Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis. Cell Research (2018) 28: 655–669.

[3] Qifan Hu, Jing Xu, Lei Wang, Yi Yuan, Ruiguang Luo, Mingxi Gan, Keru Wang, Tao Zhao, Yawen Wang, Tianyu Han,* and Jian-Bin Wang* SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma. Advanced Science (2023), DOI: 10.1002/advs.202303535

[4] Tianyu Han, Yanan Wang, Minzhang Cheng, Qifan Hu, Menglin Huang, Yuhan Liu, Wenze Xun, Jin Xu, Lei Wang, Ruiguang Luo, Yi Yuan, Keru Wang, JianbinWang* Phosphorylated SHMT2 regulates oncogenesis through m6A modification In Lung Adenocarcinoma. Advanced Science (2024), DOI: 10.1002/advs.202307834

[5] Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Xiaorui Wan, Tao Zhao, Tianyu Han, Jianbin Wang*. Lactylation enhances the activity of lactate dehydrogenase A and promotes the chemoresistance to cisplatin through facilitating DNA non-homologous end junction in lung adenocarcinoma. Advanced Science (2025). Dol:10.1002/advs.202510733

[6] Yuhan Liu, Zhujun Cheng, Jinjin Zhang, Yi Zhang, Tao Zhao, Longhua Sun,GuilanWen, Tianyu Han & Jianbin Wang*. PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma. Autophagy (2025), DOI: 10.1080/15548627.2025.2535765 (影响因子: 14.6)

[7] Tianyu Han, Meng Guo, Mingxi Gan, Bentong Yu, Xiaoli Tian & Jian-BinWang*. TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. Autophagy (2018) 14: 2035–2048.8.

[8] Tianyu Han, Pengcheng Wang, Yanan Wang, Wenze Xun, Jiapeng Lei, Tao Wang, Zhuo Lu, Mingxi Gan, Wei Zhang, Bentong Yu & Jian-Bin Wang*. FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma. Autophagy (2021) 31: 1-17.

[9] Tianyu Han, Tao Zhao, Ying Yang, Luchanghao Zheng, Minzhang Cheng, JizhuoLi, Yuhan Liu, Jianbin Wang*. Glutathione reductase induces endogenous disulfidptosis under glucose starvation in lung adenocarcinoma. Molecular Cell (2025) Revision

[10] Qifan Hu, Zuorui Wang, Wenxin Deng, Lei Wang, Jiayuan Chen, Hui Wang, Lei Jiang, Zhuo Lu, Yikai Zhao, Jia Hou, Mingxi Gan, Jing Xu, Yaoguang Hua, Yi Yuan, Menglin Huang, Lanxi Bai, Jian-Bin Wang* SIRT5-Mediated FDX1 Desuccinylation Confers Cuproptosis Resistance in Lung Adenocarcinoma.Cell Reports (2025) Revision.