PI课题组

赵冰课题组

基础信息

bingzhao@ncu.edu.cn

Z

个人简介:

南昌大学、第一附属医院双聘教授,教育部类器官资源库主任,类器官研究院常务副院长,国家“优秀青年基金”获得者,国家重点研发计划“干细胞及转化研究”首席科学家(青年),独PI,博士生导师

2013年获得清华大学细胞生物学博士学位,曾担任复旦大学生命科学学院研究员,2023年聘为南昌大学“学科方向带头人”引进人才;兼任第八届国务院学位办生物学、生物工程学科评议组副秘书长中国细胞生物学学会细胞结构与细胞行为分会副秘书长、委员中国细胞生物学学会发育生物学分会委员中国细胞生物学学会细胞治疗研究与应用分会委员中国细胞生物学学会标准工作委员会委员等。

研究方向:

研究成体干细胞命运决定机制,发展类器官培育新策略。于国际权威期刊Cell ResearchNature Chemical BiologyNature CommunicationsAdvanced ScienceCell Metabolism等发表系列性研究论文,为再生生物学和类器官技术发展提供重要基础。代表性研究成果获Nature News专访报道Nature官网主页高亮,获国际权威综述期刊Nature Reviews Molecular Cell Biology、Nature Reviews Gastroenterology & Hepatology等高度评价。

代表性论文(不超过10篇):

[1] Wei J, Cao Z, Li Q, Li X, Wang Q, Zhang Y, Zhang R, Wu X, Dai Q, Li X, Zhou Z, Sun F, Jiao S and Zhao B*. (2025) Nuclear ubiquitination permits Hippo-YAP signal for liver development and tumorigenesis. Nature Chemical Biology (生物学1Top), doi.org/10.1038/s41589-025-01901-8. (*corresponding author)

[2] Yu C, Wan X, Wei J, Wu X, Xu Z, Wang X, Mi Y, Zhang Y, Wu D, Zhou X, Le Q, Xu J, Zhao C, Sun X, Zhou X, Hong J and Zhao B*. (2025) Human meibomian gland organoids to study epithelial homeostasis and dysfunction. Protein & Cell (生物学1Top), in press.

[3] Zhou Y, Dai Q, Xu Y, Wu S, Cheng M and Zhao B*. (2025) PharmaFormer, a patient derived organoid-guided transfer learning model to predict clinical drug responses. npj Precision Oncology (医学1Top), 9:282.

[4] Gong X, Yang C, Peng J, Ding X, Yang H, Wang A, Dzakah E and Zhao B*. (2025) Vascularized organoid-on-a-chip for centimeter-scale organoid cultivation. Bio-Design and Manufacturing (医学1Top), 8:410–422.

[5] Li Q, Li X, Zhang Y, Shen Y, Lu Z, Chen W, Liu Y, Wu S, Gong X, Li X, Bechmann N, Jiang J and Zhao B*. (2025) Human adrenocortical organoids for tissue regeneration and disease modeling. Stem Cell Reports (医学1Top), doi.org/10.1016/j.stemcr.2025.102679. (Highlighted by Nature)

[6] Xu Z, Meng S, Xu R, Ma D, Dzakah E, Zheng H, Yao T, Ni C and Zhao B*. (2024) Establishment of novel colorectal cancer organoid model based on tumor microenvironment analysis. Life Medicine, 3(4):lnae027.

[7] Liang J, Wei J, Cao J, Qian J, Gao R, Li X, Wang D, Gu Y, Dong L, Yu J, Zhao B* and Wang X. (2023) In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation. Genome Biology (生物学1Top), 24:251.